The effect of salung leaf extract (Psychotria viridiflora) on blood glucose levels in mice (Mus musculus)
DOI:
https://doi.org/10.21831/jps.v30i2.87757Keywords:
Psychotria viridiflora, leaf extract, blood glucose, Mus musculus, antidiabetic, hyperglycemiaAbstract
This research aims to determine the effect of salung leaf extract (Psychotria viridiflora) on blood glucose levels in hyperglycemic mice (Mus musculus). The study used 25 mice M, musmuculus weighing 20-40 grams divided into 5 treatment groups (P). Each group consisted of 5 mice. P1: negative control (only given feed and aquades), P2: administration of alloxan 10 mg/kg body weight (BW) + glibenclamide at a dose of 0.1 mg/kg BW, P3: administration of alloxan 10 mg/kg BW + extract of P. viridiflora leaves 0.0112 g/kg BW, P4: administration of alloxan 10 mg/kg BW + extract of P. viridiflora leaves 0.0225 g/kg BW, P5: administration of alloxan 10 mg/kg body weight + extract of P. viridiflora leaves 0.0337 g/kg BW. Blood glucose measurements were conducted four times, on days 0, 6, 12, and 18, consisting of initial glucose measurement, after alloxan induction, and followed by measurements after treatment. Among the three tested doses, the highest dose (0.0337 g/kg BW) proved to be the most effective in reducing blood sugar levels in alloxan-induced M. musculus, with effectiveness comparable to the standard drug Glibenclamide. Thus, the extract of P. viridiflora leaves has strong potential as an alternative herbal antidiabetic therapy in M. musculus
Keywords: Psychotria viridiflora, Leaf Extract, Blood Glucose, Mus musculus, Antidiabetic, Hyperglycemia.
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