PEMANFAATAN EKSTRAK DAUN URTICA DIOICA L.  SEBAGAI  ANTI-AGING ALAMI DALAM SEDIAAN KRIM

Siti Maimunah; Zuhairiah Nasution; Amila Amila

doi:10.21831/jps.v25i2.34296

PEMANFAATAN EKSTRAK DAUN URTICA DIOICA L. SEBAGAI ANTI-AGING ALAMI DALAM SEDIAAN KRIM

Siti Maimunah, Universitas Sari Mutiara Indonesia, Indonesia
Zuhairiah Nasution, Universitas Sari Mutiara Indonesia, Indonesia
Amila Amila, Universitas Sari Mutiara Indonesia, Indonesia

10.21831/jps.v25i2.34296

Abstract

Penelitian ini bertujuan untuk memformulasikan ekstrak daun jelatang dalam sediaan krim dan menguji efektivitas anti-aging nya. Penelitian ini dilakukan di Laboratorium Kimia Farmasi Universitas Sari Mutiara Indonesia pada bulan Juni-Agustus 2020. Alat yang digunakan adalah skin analyzer and moisture checker. Sampel daun jelatang diperoleh dari Hutan Sibolangit, Sumatera Utara. Uji iritasi terhadap enam orang sukarelawan menggunakan krim ekstrak jelatang dengan konsentrasi tertinggi yaitu 0,5%. Pengujian aktivitas anti-aging menggunakan 18 sukarelawan wanita berusia 19-22 tahun. Parameter yang diukur meliputi kadar air, jumlah pori dan kerutan. Distribusi data dianalisis dengan Shapiro-Wilk Test dan dilanjutkan dengan Kruskal-Walls Test dan Mann-Whitney Test. Hasil penelitian ekstrak etanol daun Jelatang dapat diformulasikan dalam bentuk sediaan krim tipe A/M yang homogen, dengan pH 6, viskositas 28.000 cps, tidak menimbulkan iritasi dan stabil dalam penyimpanan selama 28 hari. Hasil analisis dengan skin analyzer menunjukkan perubahan kondisi kulit menjadi lebih baik yaitu kadar air bertambah, pori dan kerutan berkurang. Sediaan krim dengan konsentrasi 0,5% menunjukkan efektivitas anti-aging terbaik.

THE UTILIZATION OF URTICA DIOICA L. LEAVES EXTRACT AS A NATURAL ANTI-AGING IN CREAM PREPARATION

This study was aimed at formulating Nettle leaf extract in a cream formulation and testing its anti-aging effectiveness. This research was conducted at the Pharmaceutical Chemistry Laboratory of Sari Mutiara Indonesia University in June-August 2020. The tools used were skin analyzer and moisture checker. Nettle leaf samples were obtained from the Sibolangit Forest, North Sumatra. The irritation test of six volunteers used nettle extract cream with the highest concentration of 0.5%. The anti-aging activity test used 18 female volunteers aged 19-22 years. Parameters measured include moisture content, number of pores and wrinkles. The data distribution was analyzed using the Shapiro-Wilk Test and followed by the Kruskal-Walls Test and the Mann-Whitney Test. The results show that the ethanol extract of Nettle leaves can be formulated in a homogeneous type A / M cream dosage form, with a pH of 6, a viscosity of 28,000 cps, non-irritating and stable in storage for 28 days. The results of the analysis with the skin analyzer showed that the skin condition changed for the better, namely increased water content, reduced pores and wrinkles. Cream preparations with a concentration of 0.5% show the best anti-aging effectiveness.

Keywords

anti-aging, daun Jelatang, Urtica dioica L.

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DOI: https://doi.org/10.21831/jps.v25i2.34296