Swimming training on moderate intensity significantly reduces total cholesterol and bodyweight on hypercholesterolemic rat model

Anindya Mar'atus Sholikhah; Mochamad Ridwan

doi:10.21831/jk.v9i1.33362

Swimming training on moderate intensity significantly reduces total cholesterol and bodyweight on hypercholesterolemic rat model

Anindya Mar'atus Sholikhah, Universitas Negeri Surabaya, Indonesia
Mochamad Ridwan, Universitas Negeri Surabaya, Indonesia

10.21831/jk.v9i1.33362

Abstract

It is well established that regular exercise has many positive benefits on health. Exercise at the appropriate intensity and level has been shown to improve lipid profile and reduce the risk of cardiovascular disease. This study investigates the effect of swimming training on total cholesterol levels and body weight in male Wistar rats. Thirty rats weighing 150-200 grams were randomly divided into one control (C) and two treatment groups (ST=swimming training, SED=sedentary activity). Rats in control (C) group were fed a standard diet, while rats in both treatment groups were fed high-fat diet-induced hypercholesterolemia for three weeks. Rats in ST were then swim-trained at moderate intensity for 30 minutes/day, six days a week for three weeks, and rats in SED were left without exercise stimuli. Body weight was measured weekly. At the end of the experimental period, intracardiac blood samples were drawn to measure the total cholesterol level. Findings revealed that rats’ bodyweight (p=0,045) and blood cholesterol (p=0,034) in ST group were significantly lower compared to SED. It indicates that swimming exercise is shown to be effective in weight loss and reducing blood cholesterol level in hypercholesterolemic rats.

Keywords

aerobic exercise; bodyweight; cholesterol level; hypercholesterolemia; swimming training

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References

Blundell, J. E., Gibbons, C., Caudwell, P., Finlayson, G., & Hopkins, M. (2015). Appetite control and energy balance: impact of exercise. Obesity Review, 16, 67–76.

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., & Al, E. (2007). Resistance. Diabetes, 56(July), 386–389. https://doi.org/10.1016/B978-012373947-6.00332-9

Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes, 57(6), 1470–1481. https://doi.org/10.2337/db07-1403

Coelho, D. F., Chaves, D. S., Diwan, D., Ferraz, R., Poortmans, J. R., & Junior, A. H. L. (2011). Effect of high-fat diets on body composition, lipid metabolism and insulin sensitivity, and the role of exercise on these parameters. Brazilian Journal of Medical and Biological Research, 44(10), 966–972. https://doi.org/10.1590/S0100-879X2011007500107

Eberle, S. G. (2013). The Body’s Fuel Sources. In Endurance Sports Nutrition-3rd Edition. Human Kinetics Inc. https://us.humankinetics.com/blogs/excerpt/the-bodys-fuel-sources

Elsayyad, L., Allam, H., AAlzahrani, N., Gharib, A. F., Shami, A., Khalifa, O. M., & Ismail, K. A. (2020). Effect of short-term aerobic exercise on lipid profile. Annals of Clinical Medicine and Research, 1(1), 5–7.

Faitarone, A. B. G., Garcia, E. A., Roca, R. O., Ricardo, H. A., Andrade, E. N., Pelicia, K., & Vercese, F. (2013). Cholesterol levels and nutritional composition of commercial layers eggs fed diests with different vegetable oils. Brazilian Journal of Poultry Science, 15(ISSN 1516-635X), 31–38.

Harini, M., & Astirin, O. P. (2009). Blood cholesterol levels of hypercholesterolemic rat (Rattus norvegicus) after VCO treatment. Nusantara Bioscience, 1(2), 53–58.

He, N., & Ye, H. (2020). Exercise and hyperlipidemia. In J. Xiao (Ed.), Physical Exercise for Human Health (pp. 79–90). Springer. https://doi.org/10.1007/978-981-15-1792-1_5

Igarashi, Y., Akazawa, N., & Maeda, S. (2019). Effects of aerobic exercise alone on lipids in healthy east asians: A systematic review and meta-analysis. Journal of Atherosclerosis and Thrombosis, 26(5), 488–503. https://doi.org/10.5551/jat.45864

Kelley, G. A., Kelley, K. S., Roberts, S., & Haskell, W. (2012). Combined effects of aerobic exercise and diet on lipids and lipoproteins in overweight and obese adults: a meta-analysis. Journal of Obesity, 2012(986902). https://doi.org/10.1155/2012/985902

Kelley, G. A., Kelley, K. S., Roberts, S., & Haskell, W. (2013). Comparison of aerobic exercise, diet or both on lipids and lipoproteins in adults: a meta analysis of randomized controlledd trials. Clinical Nutrition, 31(2), 156–167. https://doi.org/10.1016/j.clnu.2011.11.011.Comparison

Khosravani, M., Azarbayjani, M. A., Abolmaesoomi, M., Akbari, M., Yusof, A., Abidin, N. Z., Rahimi, E., & Seyedjalali, S. (2016). Ginger extract and aerobic training reduces lipid profile in high-fat fed diet rats. European Review for Medical and Pharmocological Sciences, 20, 1617–1622.

King, M. W. (2013). Diabetes Mellitus. [Series Online]. http://thebiomedicalbiochemistrypage.org

Kraus, W., Houmard, J., Duscha, B., & Al, E. (2002). Effects of the amount and intensity of exercise on plasma lipoproteins. The New England Journal of Medicine, 347(19), 1483–1492.

Kyral, A. M., Shipherd, A. M., & Hearon, C. M. (2019). The Effect of Moderate Intensity Aerobic Exercise on Affect and Exercise Intention in Active and Inactive College Students. International Journal of Exercise Science, 12(5), 1070–1079.

Lechner, K., von Schacky, C., McKenzie, A. L., Worm, N., Nixdorff, U., Lechner, B., Kränkel, N., Halle, M., Krauss, R. M., & Scherr, J. (2020). Lifestyle factors and high-risk atherosclerosis: Pathways and mechanisms beyond traditional risk factors. European Journal of Preventive Cardiology, 27(4), 394–406. https://doi.org/10.1177/2047487319869400

Lee, B. A., & Oh, D. J. (2015). Effect of regular swimming exercise on the physical composition, strength, and blood lipid of middle-aged women. Journal of Exercise Rehabilitation, 11(5), 266–271.

Leong, X.-F., Ng, C.-Y., Jaarin, K., & Mustafa, M. (2015). Effects of repeated heating of cooking oils on antioxidant content and endothelial function. Austin Journal of Pharmacology and Therapeutics, 3(2), 1068.

Ma, H., & Shieh, K. J. (2006). Cholesterol and human health. The Journal of American Science, 2(1), 46–50.

Nakhaei, H., Mogharnasi, M., & Fanaei, H. (2019). Effect of swimming training on levels of asprosin, lipid profile, glucose and insulin resistance in rats with metabolic syndrome. Obesity Medicine, 15(April), 100111. https://doi.org/10.1016/j.obmed.2019.100111

Nissa, C., & Madjid, I. J. (2016). Potensi glukomanan pada tepung porang sebagai agen anti-obesitas pada tikus dengan induksi diet tinggi lemak. Jurnal Gizi Klinik Indonesia, 13(1), 1–6.

O’Donovan, G., Owen, A., Bird, S., & Al, E. (2005). Changes in cardiorespiratory fitness and coronary heart disease risk factors following 24 wk of moderate- or high intensity exercise of equal energy cost. Journal of Applied Physiology, 98(5), 1619–1625.

Ohuruogu, B. (2016). The contributions of physical activity and fitness to optimal health and wellness. Journal of Education and Practice, 7(20), 123–128.

Riahi, F., & Riahi, S. (2016). Effects of moderate swimming exercise on weight gain in high fat diet rats. Annals of Military & Health Sciences Research, 14(1), 46–50.

Rocha, G. L., Crisp, A. H., Oliveira, M. R. M. De, Silva, C. A., Silva, J. O., Duarte, A. C. G. O., Sene-fiorese, M., & Verlengia, R. (2016). Effect of high intensity interval and continuous swimming training on body mass adiposity level and serum parameters in high-fat diet fed rats. The Scientific World Journal, 2016. https://doi.org/10.1155/2016/2194120

Roever, L., Resende, E. S., Diniz, A. L. D., Penha, S. N., Roerver, B. A. S., Veloso, V. C., Casella, F. A., Dourado, P. M. M., & Chagas, A. C. P. (2017). Major risk factors for atherosclerosis and metabolic syndrome: The UHS. Interventional Cardiology, 09(05), 199–203. https://doi.org/10.4172/interventional-cardiology.1000578

Schubert, M. M., Desbrow, B., Sabapathy, S., & Leveritt, M. (2012). Acute exericse and subsequent energy intake. A meta analysis. Appetite, 63, 92–104. https://doi.org/10.1016/j.appet.2012.12.010

Shattat, G. F. (2014). A review article on hyperlipidemia: types, treatments, and new drug targets. Biomedical and Pharmacology Journal, 7(2). https://doi.org/10.13005/bpj/504

Shazamawati, Z. H., Alina, A. R., Mashitoh, A. S., & Juhana, M. J. T. (2013). Cholesterol oxidation products analysis in meat and poultry. Middle-East Journal of Scientific Research, 16, 67–78. https://doi.org/0.5829/idosi.mejsr.2013.16.s.100212

Sholikhah, A. M., Wirjatmadi, B., & Andriyani, M. (2018). Effects of purple sweet potatoes on oxidative stress biomarkers in rats subjected to exhaustive exercise. Health Notions, 2(2), 174–177.

Sim, J., Hwang, S., & Song, C. (2018). Hyperlipidemia as a predictor of physical functioning for stroke. Physical Therapy Rehabilitation Science, 7, 88–93. https://doi.org/10.14474/ptrs.2018.7.2.88

Sosso, F. A. E., & Raouafi, S. (2017). An overview of positive interaction between exercise and mental health. Journal of Neurology and Neuroscience, 08(04), 17–20. https://doi.org/10.21767/2171-6625.1000215

Spence, J. D., Jenkins, D. J. A., & Davignon, J. (2010). Dietary cholesterol and egg yolks: Not for patients at risk of vascular disease. Canadian Journal of Cardiology, 26(9), 336–339. https://doi.org/10.1016/S0828-282X(10)70456-6

Vafa, M. R., Haghighatjoo, E., Shidfar, F., Afshari, S., Gohari, M. R., & Ziaee, A. (2011). Effects of apple consumption on lipid profile of hyperipidemic and overweight men. International Journal of Preventive Medicine, 2(2), 94–100.

Van Baak, M. A. (1999). Physical activity and energy balance. Public Health Nutrition, 2(3 A), 335–339. https://doi.org/10.1017/S1368980099000452

Vardatsikor, G., Pandey, N. R., & Srivastava, A. K. (2013). Insulino-mimetic and anti-diabetic effects of zinc. Journal of Inorganic Biochemistry, 120, 8–17. https://doi.org/10.1016/j.jinorgbio.2012.11.006

Wang, Y., & Xu, D. (2017). Effects of aerobic exercise on lipids and lipoproteins. Lipids in Health and Disease, 16(1), 1–8. https://doi.org/10.1186/s12944-017-0515-5

Westertep, K. R., Smeets, A., Lejeune, M. P., Wouters-Adriaens, M. P. E., & Westerterp-Plantenga, M. S. (2008). Dietary fat oxidation as a function of body fat. The American Journal of Clinical Nutrition, 87, 132–135.

WHO. (2017). Cardiovascular diseases (CVDs). https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)

Wu, M. Y., Li, C. J., Hou, M. F., & Chu, P. Y. (2017). New insights into the role of inflammation in the pathogenesis of atherosclerosis. International Journal of Molecular Sciences, 18(10). https://doi.org/10.3390/ijms18102034

DOI: https://doi.org/10.21831/jk.v9i1.33362