- Silakhudin, Pusat Sains dan Teknologi Akselerator - BATAN, Indonesia


This study was aimed at determining the results of radioisotope product in particular radioisotope of fl uorine-18 at 13 MeV proton cyclotron facility. The calculation used a formulae of thick target yield on the nuclear reaction of 18 O(p,n) 18 F. This calculation is intended to ensure that the formulae and parameters used quite feasible for commissioning DECY-13 cyclotron. The calculation result has been compared with the radioisotope results of the cyclotrons in Dharmais and MRCCC Jakarta hospitals as well as the standards of the IAEA. The difference of results of calculation with comparison data is not more than 5%, which means that the calculation formulae is quite feasible for cyclotron commissioning. The calculation of fl uorine-18 product using the formulae is 1223 mCi at 30 uA proton beam current of cyclotron operation and 40 minutes of irradiation.


Cyclotron; proton; radioisotope yield calculation; fl uorine-18; commissioning

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Celler, A., Hou, X., Benard, F., & Ruth, T. J. (2011). Theoretical modeling of yields for proton induced reactions on natural and enriched molybdenum targets. Phys Med Biol, 56, 5469-5484.

Hess, E., Takács, S., Scholten, B., Tárkányi, F., Coenen, H. H., & Qaim, S. M. (2001). Excitation function of the 18 O(p,n) F nuclear reaction from threshold up to30 MeV. Radiochimica Acta, 89(6), 357-362. Diunduh dari https://www. International Atomic Energy Agency [IAEA]. (2012). Cyclotron produced radionuclides: Guidance on facility design and production of [F] FDG. IAEA Radioisotopes and Radiopharmaceuticals Series No. 3 OSE (FDG), IAEA.18

International Atomic Energy Agency [IAEA. (2016). Experimental nuclear reaction data (EXFOR) database version of May 05, 2016. Nuclear Data Center IAEA, Software Version of 2016.05.10. ISOFLEX. (2016). Isotopes for science, medicine and industry. Diunduh dari http://www.isofl Jensen, M. (2012). Particle Accelerators for PET Radionuclides. Nuclear Medicine Review, 15(C), 9-12.

Kusuma, A., Tuloh , R.A., & Suryanto, H. (2012, November). Pengoperasian cyclone 18/9 untuk Produksi radionuklida f dalam penyiapan radiofarmaka FDG di Rumah Sakit MRCCC Jakarta. Prosiding Pertemuan dan Presentasi Ilmiah Tek-nologi Akselerator dan Aplikasinya (pp. 202 212). 18

Lepera, C. G. (2016). Cyclotron productionof PET radionuclides selection and location. Cyclotope and Experimental 18 Diagnostic Imaging, The University of Texas MD Anderson Cancer Center Houston, TX. meetings/08SS.

Listiawadi F. D., Huda N., Suryanto H., & Parwanto. (2013, Oktober). Produksi radionuklida Fluor-18 untuk penandaan radiofarmaka FDG menggunakan siklotron eclipse di Rumah Sakit Kanker Darmais. Prosiding Pertemuan dan Presentasi Ilmiah Teknologi Akselerator dan Aplikasinya (p. 61). 18

Institute of Standards and Technology [NIST]. (2016). Stopping power and range tables for proton. Diunduh dari

Saied, B. M. (2013). Production of medically radionuclide 123I using p, d and He particles induced reactions. International Journal of Physics and Research (IJPR), 3(2), 17-26. 4 Shetty,

H. U., Morse, C. L., Zhang, Y., & Pike, V. W. (2013). Characterization of fast-decaying PET radiotracers solely through LC-MS/MS of constituent radioactive and carrier I.sotopologues. EJNMMI, 3(1), 1-8.

Soppera, N., Dupont, E., & Bossant, M. (2012). JANIS book of proton-induced cross-sections, OECD NEA Data Bank, June 2012.



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