THE EFFECT of 4-METHOXYBENZALDEHYDe AND CYCLOHEXANONE MOLE RATIO VARIATION ON THE SYNTHESIS of 2-(4’-METHOXYBENZYLIDENE)CYCLOHEXANONE USING MICROWAVE ASSISTED ORGANIC SYNTHESIS METHODS

Elga Riesta Puteri, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Yogyakarta
Sri Handayani, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Yogyakarta

 10.21831/jps.v22i1.15322

Abstract


This research aims to determine the effect of mole ratio variation and mole ratio which produce maximum yield. Synthesis of 2-(4’-methoxybenzylidene)cyclohexanone was done through Claissen Schmidt condensation with NaOH as catalyst. Variation of 4-methoxybenzaldehyde:cyclohexanone mole ratio were 1:1, 1:2, 1:4, 1:6, and 1:8. 2-(4’-methoxybenzylidene)cyclohexanone could be synthezied using MAOS methods for 120 seconds. Synthesis product was identified by TLC, TLC scan, spectroscopy IR, and spectroscopy 1H NMR. The result of this research showed that the variation of 4-methoxybenzaldehyde:cyclohexanone mole ratio had an effect on the synthesis of 2-(4’-methoxybenzylidene)cyclohexanone. It was proven by the different of yields which have been produced. Variation of  4-methoxybenzaldehyde:cyclohexanone mole ratio 1:1, 1:2, 1:4, 1:6, and 1:8 produced 2-(4’-methoxybenzylidene)cyclohexanone 0%; 59.272%; 64.122%; 46.782%; and 45.555% in yields respectively. The mole ratio of 4-methoxy-benzaldehyde:cyclohexanone which gives the maximum yield is 1:4.


Keywords


Synthesis; MAOS; 2-(4’-methoxybenzylidene)cyclohexanone

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References


Budimarwanti. (2009). Penyediaan senyawa berkhasiat obat secarasintesis dengan analisis retrosintesis. Prosiding Seminar Nasional Penelitian, Pendidikan dan Penerapan MIPA. FMIPA UNY, Yogyakarta.

Bruice, P. Y. (2007). Organic chemistry (5th ed.). USA: Pearson Prentice Hall.

Handayani, S., & Arty, I. S. (2008). Synthesis of hydroxyl radical scavengersfrom benzalacetone and its derivatives, Journal of Physical Science, 19(2), 61-68.

Kuhnert, N. (2002). Microwave-assisted reactions in organic synthesis-are there any non-thermal microwave effects? Angew. Chem. Int. Ed., 41(11), 1863-1866.

Liu, H., & Zhang, L. (2011). Microwave heating in organic synthesis and drug discovery. Shanghai: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences.

Nurcahyo, A. D. (2014). Pengaruh Variasi rasio mol sinamaldehida-aseton pada sintesis 6-fenil-3,5-heksadien-2-on (Sinamalaseton) menggunakan metode MAOS (Microwave Assisted Organic Synthesis) (Skripsi tidak diterbitkan). FMIPA UNY, Yogyakarta.

Pavia, D. L., Lampman, G. M., Kriz, G. S., & Vyvyan, J. R. (2001). Introduction to spectroscopy. Philadelphia: Sauders College.

Putri, S. A. (2009). Aplikasi reaksi canizzaro terhadap benzaldehida dan p-Anisaldehida dengan kondisi tanpa pelarut (Skripsi tidak diterbitkan). FMIPA UNS, Surakarta.

Sekhon, B. S. (2010). Microwave-assisted pharmaceutical synthesis: An overview. International Journal of PharmTech Reasearch, 2(1), 827-833.

Silverstein, R. M., Webster, F. X., & Kiemle D. J. (2005). Spectrometric identification of organic compounds (7th ed.). New York: John Wiley & Sons Inc.

Wardencki, W., Curylo, J., & Namiesnik, J. (2005). Green chemistry-current and future issues. Polish Journal of Evironmental Studies, 14(4), 389-395.

Yuliyani, N. R. (2016). Pengaruh variasi rasio mol sikloheksanon-benzaldehida pada sintesis benzilidinsikloheksanon (Skripsi tidak diterbitkan). FMIPA UNY, Yogyakarta.




DOI: https://doi.org/10.21831/jps.v22i1.15322

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