Integrative Ethnopharmacological and In-Silico Strategy for Identifying Indonesian Jamu to Enhance Athletic Stamina
DOI:
https://doi.org/10.21831/jomassh.v2i2.2888Keywords:
Athlete stamina, Drug discovery, Ethnopharmacology, Jamu, Molecular docking, PhytochemicalsAbstract
Introduction: Athletic stamina is a multifactorial trait involving metabolic, endocrine, immune, and stress-response pathways. This study aimed to integrate ethnopharmacological data with in-silico approaches to identify Indonesian natural products with potential stamina-enhancing effects. Methods: Health-related jamu formulations from the KNApSAcK database were analyzed using pharmacognosy scoring and correspondence analysis to prioritize plants. Compounds were filtered by drug-likeness and ADMET, followed by target prediction, molecular docking, and integration into a Jamu Formulation Score (JFS). Results: A total of 41 priority plants and 31 candidate compounds were identified, with several showing strong binding affinities toward key targets such as oestrone with ESR1 and withanolide with NFKB1. The results demonstrated convergence between ethnopharmacological relevance and molecular plausibility in supporting stamina-related activity. Conclusions: This integrative approach effectively prioritizes evidence-based natural product candidates for stamina enhancement. The findings provide a rational foundation for future experimental validation and modern jamu formulation development.
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