The Effect of Combination Psophocarpus Tetragonolobus and Pisum sativum Extract on The Histological Structure of The Liver, Kidney and Stomach of Rattus norvegicus
DOI:
https://doi.org/10.21831/ijobi.v1i2.214Keywords:
winged bean, pea, liver, kidney, stomach, white ratAbstract
This research aim to determine the effect of the extract of winged bean (Psophocarpus tetragonolobus) and peas (Pisum sativum) toward histological structure of the liver, kidneys, and stomach of white rats (Rattus norvegicus).
The objects of this research are twenty (20) white rats female wistar strain with ±100-200 grams of weigh which had never been pregnant. White rat samples are divided into 1 group as a control (P0) and 3 treatment groups with P1 25 mg/kgBB of winged bean extract + 75 mg / kgBB of peas extract, P2 50 mg / kgBB of winged bean extract + peas extract 50 mg / kgBB, and P3 winged bean extract 75 mg / kgBB + peas extract 25 mg / kgBB given for 21 days. Each group consist of 5 repetitions. The analysis used the One Way Anova test, it the results were significant, and then proceed with the Duncan's Multiple Range Test (DMRT) test. To determine the trend of the effect of winged bean seed extract and pea on the histological structure of the liver, kidneys, and stomach, descriptive analysis was performed.
The results showed that the extract of winged bean and pea had no significant effect (p> 0.05) on the histological structural damage of the liver and kidneys of white rats. Giving winged bean extract) and peas extract on the histological structure of the stomach of white rats in all treatment groups was under normal conditions.
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References
Almasyhuri, A., Yuniati, H., & Slamet, D. S. (1990). Kandungan asam fitat dan tanin dalam kacang-kacangan yang dibuat tempe. Nutrition and Food Research, 13, 159550.
Eiffellia, A. R. (2010). Pengaruh pemberian kacang hijau (Phaseolus radiatus) terhadap perbaikan struktur histologis mukosa lambung mencit (Mus musculus) yang diinduksi aspirin. Skripsi. Surakarta : UNS.
Erlinda, D. (2017). Efek Diuretik Ekstrak Etanol Daun Alpukat (Persea Americana Mill.) Terhadap Histologi Lambung Tikus Putih Jantan (Rattus norvegicus) Strain Wistar. Jember : Universitas Jember.
Frank C. Lu. (1995). Toksikologi Dasar, Asas, Organ Sasaran, dan Penilaian Resiko. (Alih Bahasa : Edi Nugroho). Jakarta : UI Press.
Gamiswarna, S. G., Rianto, S., Suyatna, F.D., Purwantyastuti, dan Nafriald (1995). Farmakologi dan Terapi.Edisi 4. Jakarta: Bagian Farmakologi Fakultas Kedokteran Universitas Indonesia.
Guyton, A. C. & Hall. (1997). Fisiologi Kedokteran. Edisi 9. Jakarta :Penerbit Buku Kedokteran.
Harisson. (1999). Prinsip – Prinsip Ilmu Penyakit Dalam : Edisi 13 Volume 1. Jakarta : EGG.
Himawan, S. (1992). Patologi. Jakarta: Penerbit Buku Kedokteran EGC.
Kaihena, M., & Samson, E. (2019). Efektivitas Infusa Daun Kecipir (Psophocarpus tetragonolobus (L.) DC) Terhadap Tikus Putih (Rattus norvegicus) Model Malaria. Rumphius: Pattimura Biological Journal, 1(1), 026-033.
Khan, M. R. A., Mahmud, F., Reza, M. A., Mahbub, M. M., Shirazy, B. J., & Rahman, M. M. (2017). Genetic diversity, correlation and path analysis for yield and yield components of pea (Pisum sativum L.). World Journal of Agricultural Sciences, 13(1), 11-16.
Safithri, F. (2018). Mekanisme Regenerasi Hati secara Endogen pada Fibrosis Hati. MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan, 2(4), 9-26.
Saragih, R., Saptadi, D., Zanetta, C. U., & Waluyo, B. (2018). Keanekaragaman Genotipe-genotipe potensial dan penentuan keragaman karakter agro morfologi ercis (Pisum sativum L.). Jurnal Agro, 5(2), 127-139.
Wahyuni, S. (2010). Karakterisasi senyawa bioaktif isoflavon dan uji aktivitas Antioksidan dari ekstrak tempe berbahan baku buncis (Phaseolus vulgaris) dan kecipir (Psophocarpus tetragonolobus). Doctoral dissertation. Jawa tengah : UNS (Sebelas Maret University).
Yuliana, E. F. (2019). Gambaran Histopatologi dan Kemampuan regenerasi Korteks Ginjal Tikus Putih Jantan Dewasa setelah Penghentian Pajanan Monosodium Glutamat. Jurnal Mahasiswa PSPD FK UniversitasTanjungpura, 5(1).
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