Applications and Future Potential of X-ray Diffraction in Pharmaceutical Polymorphism: A Literature Review

Authors

  • Rizki Rava Dwiputra Departement of Pharmacy, University of Singaperbangsa Karawang
  • Jasmine Rahma Saputri Departement of Pharmacy, University of Singaperbangsa Karawang
  • Marsah Rahmawati Utami Departement of Pharmacy, University of Singaperbangsa Karawang

DOI:

https://doi.org/10.21831/ijoce.v7i2.79071

Abstract

Polymorphism in drug compounds is a significant phenomenon in pharmacy because it affects physicochemical properties such as solubility, stability, and bioavailability, which impact the effectiveness and safety of drugs. X-ray diffraction (XRD) is one of the methods that can be used to identify and analyze the polymorphic properties of drug compounds. This article reviews the utilization of XRD in various studies, showing that this method is effective for identifying polymorphism, detecting changes in crystal forms, monitoring crystalline phase transitions, and characterizing the formation of new crystalline phases. Although very useful, XRD has limitations in detecting amorphous phases and requires optimal sample preparation. For more comprehensive results, XRD is often combined with other techniques such as DSC and FTIR. Overall, XRD plays an important role in drug development and quality control, and this technology is expected to continue evolving, including its ability to directly monitor the crystallization process to enhance drug quality and stability.

Downloads

Published

2024-12-02

How to Cite

[1]
Dwiputra, R.R. et al. 2024. Applications and Future Potential of X-ray Diffraction in Pharmaceutical Polymorphism: A Literature Review. Indonesian Journal of Chemistry and Environment. 7, 2 (Dec. 2024), 93–103. DOI:https://doi.org/10.21831/ijoce.v7i2.79071.

Issue

Vol. 7 No. 2 (2024): DECEMBER 2024

Section

Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.