Chemistry and Biology of Cyanides: A Literature Review

Abstract

The term cyanide is used to describe compounds that contain the cyano, -C≡N, group. The cyanides exist in nature as inorganic as well as organic compounds in the forms of gas or liquid such as HCN, CNCl and acetonitrile, or solids such as NaCN, KCN, and Ca(CN)₂. Cyanide compounds are also found in addible plants as cyanogenic glycosides. Compounds that can release cyanide are known as cyanogenic compounds. HCN has a low boiling point (25.63 ^oC) and is as weakly acidic with a pKa 9.2. It partially ionizes in water to give the cyanide anion, ^-CN. Cyanide ion from salt reacts with acid to give HCN, but at high pH (8-10), it remains as cyanide ion even if the temperature of the water is 80.0-100.0 °C. Cyanide is one of the deadliest poisons, LC₅₀ is 1.1 and <5.0 mg/kg for HCN and NaCN, which can cause death to those who come into contact within a few minutes or hours of exposure, depending on the level and route of exposure. It is a rapidly acting, potentially deadly chemical that interferes with the body's ability to use oxygen. Due to its toxicity, cyanide has many roles in industry such as pesticides and medicines as nitrile-containing pharmaceuticals. Organic compounds that have a âˆ’C≡N functional group are called nitriles. Over 30 nitrile-containing pharmaceuticals are currently marketed for a diverse variety of medicinal indications with more than 20 additional nitrile-containing leads in clinical development. In addition, over 120 naturally occurring nitriles have been isolated from terrestrial and marine sources.  In plants, cyanides are usually bound to sugar molecules in the form of cyanogenic glycosides. Hydrogen cyanide can be released from hydrolysis of cyanogenic glycosides which are commonly present in edible plants. Because it is a relatively common toxin in the environment, the body can detoxify a small amount of cyanide. The major route of metabolism for cyanides is detoxification in the liver by the mitochondrial enzyme rhodanese, which catalyzes the transfer of the sulfane sulfur of thiosulfate to the cyanide ion to form thiocyanate. Ingested cyanide may be countered by administering antidotes, such as natural vitamin B₁₂ and sodium thiosulfate, that detoxify cyanide or bind to it.