MICROALBUMINURIA ON DIABETES PATIENTS MELLITUS TYPE 2 HYPERTENSIVE

Evy Yulianti, FMIPA UNY, Indonesia

Abstract


Diabetes mellitus (DM) is a metabolic aberration that can cause some complications, including the occurrence of diabetic nephrophaty (DN). Patients with type 2 DM usually have hypertension likely to double compared to the non-DM patients. Prevalence of hypertension is usually greater in patients with type 2 DM with increased albumin in their urine. Data estimate that microalbuminuria is a value as the index of vaskuler damage, especially in the DM and hypertension. The objective of this research is to investigate microalbumin in type 2 DM patients normotensif and type 2 DM patients hypertensif and assess the influence of blood pressure as risk factors in the occurrence of DN in type 2 DM patients.

Subjects of this study are 87 people with type 2 DM normotensif and hipertensif consisting of 54 ND patients and 33 non ND. Microalbumin is measured with the dipstick microalbumin and blood pressure with a sphygmomanometer. The comparison between the control group who examined was showed with X2 with two degrees of freedom with significance level (alpha) 0.05 and odds ratio calculation is done.

Results obtained in this research is people with type 2 DM hypertensif have a higher frequency in the DN group (67.3%) compared to the non-DN (p = 0.043) with OR = 2.64.

Conclusion of this research is the positive result of the microalbumin examination is bigger in the people with type 2 DM hypertensif and hypertension is a risk factor for occurrence of ND in type 2 DM patients


Keywords


type 2 diabetes mellitus; diabetic nephropathy; hypertension

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References


Bloomgarden, Z.T., 2005, Diabetic Nephropathy, Diabetes Care, 28, 745 – 751.

Border,W.A.Fogo,A.B.Abboud, H.E.Noble, N.A. Schnaper, H.W.Kelly,V.E.1999. Renal Disease Progression. Research Progress Reviews.

Bradham, D. M., Igarashi, A., Potter, R. L., and Grotendorst, G. R. 1991. Connective tissue growth factor: a cysteine-rich mitogene secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J. Cell Biol. 114, 1285–1294 Brownlee M. The Pathobiology of Diabetic Complications A Unifying Mechanism DIABETES

Buraczynska M, Gaszczyk I. B, Borowicz E, Ksiazek A. TGF- β1 and TSC-22 Gene Polymorphisms and Susceptibility to Microvascular Complications in Type 2 Diabetes Nephron Physiol 2007;106:p69–p75

Cardiovascular and Renal Drugs Advisory Committee. 2002. Hypertension and Type 2 Diabetic Renal Disease Worldwide Clinical esearch and Development FDA Advisory Briefing Book for Avapro

Eddy, A.A., 2004, Proteinuria and Interstitial Injury, Nephrol Dial Transplant, 19, 277 – 281.

Grotendorst, G. R.1997. Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev. 8, 171–179

Grundy S. M. Benjamin, I J., Burke G L., Chait A, Eckel R H.,; Howard B. V., Mitch W, Smith S. C., Jr, Sowers J R. 1999 .Diabetes and Cardiovascular Disease A Statement for Healthcare Professionals From the American Heart Association. American Heart Association, Inc.

Khan. Z A.,, Farhangkhoee H and Chakrabarti S, Towards Newer Molecular Targets for Chronic Diabetic Complications Current Vascular Pharmacology, 2006, 4, 45-57

Leask, A., Denton, C. P., and Abraham, D. J. 2004. Insights into the molecular mechanism of sustained fibrosis: The role of connective tissue growth factor in scleroderma. J. Invest. Dermatol. 122, 1–6

LeRoy, E. C., Trojanowska, M. I., and Smith, E. A. 1990. Cytokines and human fibrosis. Eur. Cytokine Netw. 1, 215– 219 Mikroalbuminuria pada Penderita Diabetes Mellitus Tipe 2 Hipertensif (Evy Yulianti) 95 Loon N R, Diabetic Kidney Disease: Preventing Dialysis and Transplantation CLINICAL DIABETES .Volume 21, Number 2, 2003

Lydakis C. and Lip G.Y.H. Microalbuminuria and cardiovascular risk.Review QJM. Q J Med 1998; 91:381–391

Mansjoer, A. Triyanti, K. Savitri, R. Wardhani, W.I. Setiowulan, W.2001 Kapita Selekta Kedokteran. Edisi 3. Penerbit Media Aesculapius. FK UI Jakarta.

Mǖller, G.A., Zeisberg, M., dan Strutz, F., 2000, The Importance of Tubulointerstitial Damage in Progressive Renal Disease, Nephrol Dial Transplant, 15 [suppl 6], 76 – 77.

Oyama, F., Murata, Y., Suganuma, N., Kimura, T., Titani, K., and Sekiguchi, K. 1989. Patterns of alternative splicing of fibronectin pre-mRNA in human adult and fetal tissues. Biochemistry 28, 1428–1434

Peterdi, J. P., Kang, J.J., Toma, I. 2008. Activation of the renal renin–angiotensin system in diabetes new Concepts. Nephrol Dial Transplant. 23: 3047–3049

Reddy, G.R., Kotlyarevska, K., Ransom, R.F., and Menon, R.K., 2008, The podocyte and diabetes mellitus : is the podocyte the key to the origins of diabetic nephropathy?, Curr Opin Nephrol Hypertens, 17, 32 – 36.

Schrijvers B.F., de Vriese A.S , and Flyvbjerg A. From Hyperglycemia to Diabetic Kidney Disease: The Role of Metabolic, Hemodynamic, Intracellular Factors and Growth factors/Cytokines Endocrine Reviews 2004 :25(6):971–1010

Svensson, M. 2003. Metabolic Aspects on Diabetic Nephropathy Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden

Thomassian,B. Mennito,A.S. 2005 The Dental Patient with Diabetes. Foundation in Continuing Dental Education.

Vora,J.,Diabetic Nephropathy: Detection and Treatment of Renal Disease in Patients with Diabetes Proceeding Advanced Studies in Medicine Vol. 4 (10G) n 2004

Wendt T M., Tanji N. Guo J, Kislinger T R., Qu W. Lu Y. Bucciarelli L G., Rong L.L. Moser B. Markowitz G S., Stein G. Bierhaus A. Liliensiek B. Arnold B. Nawroth P P. Stern D M., D’Agati V D., and Schmidt A.M RAGE Drives the Development of Glomerulosclerosis and Implicates Podocyte Activation in the Pathogenesis of Diabetic Nephropathy. American Journal of Pathology, Vol. 162, No. 4, April 2003

World Health Organization.2003.Screening for Type 2 Diabetes.Report of a World Health Organization and International Diabetes Federation meeting Department of Noncommunicable Disease Management Geneva

Yeung .V.T.F,Lee. K.F.,Chan. S.H.,Ho, L.F.,Leung, S.K., Wong, H.Y. MicroAlbuminuria Prevalence Study(MAPS) in hypertensive type 2 diabetic patients in Hong Kong .Hong Kong Med J 2006;12:185-90




DOI: https://doi.org/10.21831/jps.v14i1.695

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